Therefore, the ultimate goal of our study was to improve the accuracy of the draft genome of H. 11 using the example of Echinococcus granulosus, highlight the possible limitations of published draft genomes of selected tapeworm species, one being the fact that they were sequenced using only Illumina short reads technology. diminuta is available only as a draft genome acquired as part of the 50 Helminth Genomes project initiative 10. Hymenolepis diminuta has a worldwide distribution as an intestinal parasite of rodents (primarily rats) and humans 9, and the tapeworms of the genus Hymenolepis are considered to be among the most frequent causative agents of the human cestodiasis 1.ĭespite its importance as a model organism, the genome of H. diminuta was chosen for the present study since it is commonly used in studies of new therapeutics, biochemical processes, immune responses and other host-parasite interrelationships during cestodiasis 3, 4, 5, 6, 7, 8 and is considered the most important model species in experimental cestodology. diminuta is a well-described representative of the class Cestoda, the large group of parasitic flatworms that includes members known to be serious pathogens of vertebrate animals and humans 1, 2. Our study used hybrid genome sequencing to examine the genome of the tapeworm Hymenolepis diminuta by three technologies: Illumina sequencing pair-end, Illumina mate-pair and MinION Oxford Nanopore DNA sequencing. Modern genomic tools, especially those based on a combination of multiple methods, allow detailed analyses of genome structure. The study of the genomics and transcriptomics of parasite model species has led to advances in the basic aspects of parasite biology, as well as new trends in human and veterinary medicine.
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